Studying the brain remains one of the most challenging endeavors in neuroscience. Researchers have explored various methods for live imaging and stimulation of deep brain activity.
Reviewed by Lily Ramsey, LLMOct 25 2023 One such method is multiphoton excitation using pulsed infrared light. This type of light is weakly absorbed by tissues and can penetrate through the bone and deep into organs like the brain. However, it has its limitations to produce focused images and to control cellular activity with precision.
The study, published at Angewandte Chemie journal, was led by Dr. Pau Gorostiza, ICREA Research Professor, member of CIBER-BBN and Leader of the Nanoprobes and nanoswitches group at IBEC and by Dr. Pablo Loza-Álvarez, head of the Super resolution microscopy and Nanoscopy lab at ICFO. The power of light Light can be harnessed to enable targeted drug action within specific areas of the body through photopharmacology. This innovative approach involves modifying the chemical structure of a drug by adding a light-activated molecular switch, ensuring the drug activates only when exposed to a particular color of light.
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