A team of biologists has discovered how to awaken neural stem cells and reactivate them in adult mice. Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation i
Newly produced neurons in the dentate gyrus with cell nuclei and a marker for immature neurons . Credit: Knobloch Lab – UNIL
A team of biologists has discovered how to awaken neural stem cells and reactivate them in adult mice. Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation is still poorly understood. A team led by scientists from the Universities of Geneva and Lausanne has discovered the importance of cell metabolism in this process and identified how to wake up these neural stem cells and reactivate them.
‘‘We found that mitochondria, the energy-producing organelles within cells, are involved in regulating the level of activation of adult NSCs,’’ explains Francesco Petrelli, research fellow at UNIL and co-first author of the study with Valentina Scandella. The mitochondrial pyruvate transporter , a protein complex discovered eleven years ago in Professor Martinou’s group, plays a particular role in this regulation. Its activity influences the metabolic options a cell can use.
Reference: “Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells” by Francesco Petrelli, Valentina Scandella, Sylvie Montessuit, Nicola Zamboni, Jean-Claude Martinou and Marlen Knobloch, 1 March 2023,
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