Scientists explore efficacy of small molecule drugs against severe COVID-19 in vitro biorxivpreprint amsterdamumc SmallMoleculeDrug SARSCoV2 COVID19 Coronavirus Efficacy
Interview conducted by Pooja Toshniwal PahariaDec 29 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers evaluated the efficacy of small molecule drugs against severe acute respiratory syndrome coronavirus 2 in vitro.
A macrophage activation assay, capable of evaluating compound efficacy and potency against anti-S-targeted inflammatory responses, was developed and used to screen authorized investigational small molecule inhibitor molecules. The selectivity and potency against anti-S-mediated hyper-inflammation were quantified based on the IC50 values for the activation of macrophages. M-CSF and il=10 -differentiated MDAMs were used.
Results Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Multiple PI3K and SYK inhibitors counteracted the inflammation mediated by anti-S immunological complexes. Entospletinib, an SYK inhibitor, was identified as the most promising drug candidate to combat anti-SARS-CoV-2 S IgG-induced hyper-inflammation, disruption of endothelial barrier integrity, thrombocyte adhesion, and formation of thrombus.
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