Scientists performed a kind of ‘molecular archaeology’ to re-create a 50,000 year-old gene sequence to see how a malaria parasite switched from infecting gorillas to being able to infect humans
LONDON - Scientists who resurrected a 50,000-year-old gene sequence have analyzed it to figure out how the world’s deadliest malaria parasite jumped from gorillas to humans - giving insight into the origins of one of human history’s biggest killers.
In the case of the most deadly form of the malaria parasite, Plasmodium falciparum, this analysis found that it gained its ability to infect human blood cells from a section of DNA that had transferred from a gorilla parasite. “The fact that this ancestral RH5 protein was able to bind to red blood cell receptor ... from both humans and gorillas immediately provided a molecular explanation for how P. falciparum evolved to infect humans,” said Francis Galaway, who co-led the research team from Britain’s Wellcome Sanger Institute and France’s Montpelier University.
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