Scientists have transplanted human brain cells into the brains of baby rats, where the cells grew and formed connections, according to new research.
It's part of an effort to better study human brain development and diseases affecting the most complex of organs, which makes us who we are but has long been shrouded in mystery.
To make the brain organoids, Stanford University scientists transformed human skin cells into stem cells and then coaxed them to become several types of brain cells. Those cells then multiplied to form organoids resembling the cerebral cortex, the human brain's outermost layer, which plays a key role in things like memory, thinking, learning, reasoning and emotions.
To examine a practical use of this approach, scientists transplanted organoids into both sides of a rat's brain: one generated from a healthy person's cells and another from the cells of a person with Timothy syndrome, a rare genetic condition associated with heart problems and autism spectrum disorder.
Dr. Flora Vaccarino of Yale University – who previously grew lumps containing cerebral cortex that were made with DNA from people with autism — said the study moves the field forward.
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