A London man has been in remission from HIV for a year and a half, without drugs, after receiving a stem cell transplant of virus-resistant cells — raising the prospect that he has become the second person to ever be cured of the disease.
Timothy Ray Brown, seen on Monday in Seattle, was the first person to be cured of HIV infection, more than a decade ago. Now researchers are reporting a second patient has lived 18 months after stopping HIV treatment without sign of the virus following a stem cell transplant.
A second set of"Boston patients," who received stem cell transplants with functioning CCR5 genes, also experienced marked reductions in the reservoir of HIV in their cells — and were able to go without treatment for months, showing that the transplant itself played a role in knocking back the virus. But their temporary results also suggested that the aberrant gene was necessary for a sustained cure.
Several patients who have received such transplants since Brown's successful treatment have died of the underlying cancer, several HIV researchers noted.
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