In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Laura Kuett, a Ph.D. student in Systems Biology, about the promise of 3D Imaging Mass Cytometry.
Interview conducted by Danielle Ellis, B.Sc.Oct 17 2023 Thought LeadersLaura KuettPh.D. Student University of Zurich
In imaging mass cytometry, the tissue is stained with those metal tag antibodies, and then the tissue is ablated by laser to capture the counts of those metals in each tissue spot. These intensities are then translated into an image. What are the benefits of using this technique when analyzing tissues compared to the other techniques that are available at the moment? The main benefits of imaging mass cytometry are the high multiplexity, the ability to target 40 proteins simultaneously, and the spatial information we can get. This can provide great insights into tissue biology.
Another SLAS EU track for this year is “Biology Unveiled.” How does the subsequent analysis of mass cytometry images unveil relevant biological information? We live in a 3D world, and biology happens in 3D. Tissues are inherently 3D structures. Seeing the tissues visually in 3D and interacting with those 3D models would facilitate a greater understanding of tissue biology. I hope researchers can use these methods to learn more about tissue biology in health and disease.
As a Ph.D. student in the field of oncology, how hopeful are you about the future of cancer research? I am very hopeful about the future of cancer research, coming from the field of breast cancer. Breast cancer is a very well-studied cancer type because of the huge amount of funding that has gone into breast cancer research.
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