People with intermediate risk, localized prostate cancer can be treated as effectively using fewer and higher doses of radiation therapy delivered over five treatment sessions as they can with lower doses delivered over several weeks, a new phase III randomized trial suggests.
Reviewed by Lily Ramsey, LLMOct 3 2023 The findings, which are the latest from a series of studies investigating the benefits of stereotactic body radiation therapy for people diagnosed with prostate cancer, will be presented Monday at the American Society for Radiation Oncology Annual Meeting.
Nicholas van As, MD, principal investigator for the trial, consultant clinical oncologist and Medical Director of The Royal Marsden NHS Foundation Trust and professor at the Institute of Cancer Research in London SBRT is an advanced form of radiation therapy that shrinks or destroys tumors with fewer, higher doses of radiation delivered in a small number of outpatient sessions. This approach uses advanced imaging and treatment planning techniques to deliver radiation with pinpoint accuracy, minimizing damage to surrounding healthy tissue.
Related StoriesDrawing from 38 centers across the UK and Canada, PACE B researchers enrolled 874 people who preferred radiation treatment or were unsuitable for surgery. The median age was 69.8 years old. Side effects were low in both groups, and not significantly different between treatment arms. At five years post-treatment, 5.5% of patients who received SBRT experienced grade 2 or higher side effects affecting the genital or urinary organs, compared to 3.2% in the conventional group . Only one person in each arm of the study experienced grade 2 or higher gastrointestinal side effects .
"One of the things this study demonstrated is that outcomes of high-quality radiation therapy are outstanding," he said. "We've become much more precise at tracking and reaching the targets. We're able to put high doses of radiation in the right place and avoid putting high doses in areas we don't want it."
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