From ESCCongress, Drs DrM_ODonoghue and vlgmrc discuss the latest analysis regarding aspirin monotherapy compared to P2Y12 inhibitor monotherapy in patients with CAD. CardioTwitter
Hi. I'm Dr Michelle O'Donoghue. I'm here at ESC Congress 2022, which is now back in person here in Barcelona. It's been very hot. I'm joined by Dr Marco Valgimigli, who almost needs no introduction at this point as he's been a leader in the field of antiplatelet therapy. I'm really specifically thinking about duration.asking the question, how does aspirin monotherapy compare to P2Y12 inhibitor monotherapy? This is a very hot topic.. You're correct.
That gave us 25,000 patients where the comparison took place in a randomized manner. For the P2Y12 inhibitor, we have both ticagrelor and clopidogrel, but unfortunately, there is no study comparing prasugrel vs aspirin. Perhaps there will be in the future.It's such an important question because, as you say, people are moving toward wanting to discontinue DAPT on the earlier side.
The primary endpoint that we prespecified was a composite of cardiovascular death, MI, and stroke, which is a classic endpoint, that was significantly reduced by 12% with a significantvalue and a number needed to treat in the range of 120. There was some benefit but not a massive benefit. You will need to treat 120 patients to prevent one component of that endpoint with a P2Y12 inhibitor instead of aspirin.
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