A new study suggests that people who take certain diabetes drugs may have a lower risk of getting the 'plaques' that build up in the brains of people with Alzheimer's disease.
, which results in chronically high blood sugar levels. Some studies have found that people with Alzheimer's also have problems with insulin resistance -- and researchers have speculated that may contribute to the brain degeneration seen in the disease.Animal research has suggested DDP-4 inhibitors can reduce brain inflammation and protect brain cells from Alzheimer's-like injury.
On average, the researchers found, patients on DDP-4 inhibitors had less amyloid buildup than either the diabetes-free patients or those on other diabetes medications. And over the next few years, they also showed a slower decline on tests of memory and thinking.Maria Carrillo, chief science officer for the Alzheimer's Association, stressed that the study cannot prove DDP-4 inhibitors slow down the dementia process.
Insulin resistance, as well as high blood sugar, may partly explain it, according to the Alzheimer's Association. Carrillo noted that this study did not look at patients' long-term blood sugar control -- and whether that had any role in their rates of decline over time.
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