Some of Us Are Part-Neanderthal, And It Could Affect How You Process Medicines

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Some of Us Are Part-Neanderthal, And It Could Affect How You Process Medicines
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Life on the blood-thinning agent warfarin involves the careful calculation of each dose. Too little, and it could be ineffective. Too much, and there is the risk of uncontrollable bleeding.

into every corner of the globe over tens of thousands of years – paused to raise families with previous groups of migrants along the way.passed down from this intermingling is yet to be fully appreciated, though year by year, researchers uncover hints in how genes that evolved in long-lost populations could contribute to differences in our own biology.In many cases, these variations might be fairly trivial.

Of course, some of these variations in structure do a better job at metabolising pharmaceuticals than others, meaning the version of CYP2C9 you inherit could determine how long your dose of medicine sticks around in your body. CYP2C9*2 seems to pop up rather frequently with other variants classed as CYP2C8*3, especially in individuals in the same families. This wouldn't be so odd, if not for the fact they happened to be separated by tens of thousands of bases of DNA.

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