Space travel can alter geneexpression in white blood cells, weakening our immunesystem frontiersin frontiersin
, astronauts while in space would have limited access to care, medication, or evacuation," said Dr. Guy Trudel, a rehabilitation physician and researcher at The Ottawa Hospital and professor at the Department of Cellular and Molecular Medicine of the University of Ottawa.
In contrast, the authors don't yet know how long it takes before immune resistance is fully back to its pre-flight strength. Tthe length of this period is likely to depend on age, sex, genetic differences, and childhood exposure to pathogens. The authors hypothesized that the change in gene expression of leukocytes under microgravity is triggered by"fluid shift," whereis redistributed from the lower to the upper part of the body, including the lymphatic system. This causes a reduction in plasma volume by between 10% and 15% within the first few days in space. Fluid shift is known to be accompanied by large-scale physiological adaptations, apparently including altered gene expression.
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