Discontinuing stable, long-term opioid therapy may not be necessary for patients who show no signs of misuse ― and it could even be safer than tapering or abrupt discontinuation, new research suggests.
The risk differences between taper vs stable dosage were 0.15% , and the risk differences between abrupt discontinuation and stable dose were 0.33% . The risk ratios associated with taper vs stable dosage and abrupt discontinuation vs stable dosage were 1.15 and 1.34 , respectively.
"Policies establishing dosage thresholds or mandating tapers for all patients receiving long-term opioid therapy are not supported by existing data in terms of anticipated benefits even if, as we found, the rate of adverse outcomes is small," the investigators write. By contrast, the current study investigators specifically excluded patients with OUD/opioid misuse but still found a"slight increase in risk for opioid overdose and suicide, even when excluding for potential confounders," he said.
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