Recent research on mice reveals that as the animals age, the most significant changes occur in white matter, the tissue responsible for conveying messages throughout the brain. Many of us, upon reaching middle age, observe a decline in memory and cognitive abilities. However, the exact molecular ch
A recent study in mice indicates that significant molecular changes in aging brains occur in the white matter, which is vital for transmitting brain signals. The research also showed that plasma from young mice could potentially slow age-related cognitive decline, offering insights into normal aging and neurodegenerative diseases.
However, a recent study conducted in mice has revealed that the most significant changes tend to occur in the white matter of the brain, a type of nervous system tissue that’s integral to transmitting signals across the brain. The study also examined two treatments — caloric restriction and infusions offrom young mice — that affect certain regions of the brain, with the plasma appearing to slow the age-related decline.
The team used these genes to develop a common aging score, assessing how gene activity in different regions of the brain change with age. Past work has shown that aging disrupts an otherwise stable gene expression pattern in the brain, turning on genes that regulate inflammation and the immune response, and turning off genes responsible for protein and collagen synthesis. The inflammation and immune response affect the integrity of the myelin sheath, the insulation layer around nerves responsible for transmitting signals across the brain.
The researchers found that the dietary intervention caused genes associated with circadian rhythms to turn on, while the plasma intervention turned on genes involved in stem cell differentiation and neuronal maturation that led to selective reversal of age-related gene expression.
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