Strong RSV vaccine data lifts hopes after years of futility

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Strong RSV vaccine data lifts hopes after years of futility
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Efforts to create a vaccine have failed for decades but some recent promising studies are raising hopes that one might finally be getting close.

New research shows vaccinating pregnant women helped protect their newborns from the common but scary respiratory virus called RSV that fills hospitals The preliminary results buoy hope that after decades of failure and frustration, vaccines against RSV may finally be getting close.

The vaccine quest isn’t just to protect infants. RSV is dangerous for older adults, too, and both Pfizer and rival GSK recently announced that their competing shots also proved protective for seniors. In the U.S., about 58,000 children younger than 5 are hospitalized for RSV each year and several hundred die. Among adults 65 and older, about 177,000 are hospitalized with RSV and 14,000 die annually.WHY IS THERE NO VACCINE?

Even today’s modern RSV vaccine candidates were tested first in older adults, not children, he noted.Modern vaccines tend to target the outer surface of a virus, what the immune system sees when a germ invades. For RSV, that target is the so-called F protein that helps the virus latch onto human cells. Again there was a hurdle: That protein is a shape-shifter, rearranging its form before and after it “fuses” to cells.

The older-adult data “looks fantastic,” said McLellan, who has closely followed the vaccine development. “I think we’re on the right track.”

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