Structure-destabilizing mutations transform Bcl-2 from an antiapoptotic protein into a proapoptotic protein

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Structure-destabilizing mutations transform Bcl-2 from an antiapoptotic protein into a proapoptotic protein
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Bcl-2 family proteins are highly conserved molecules that play a crucial role in regulating the release of apoptotic proteins from mitochondria. They possess Bcl-2 homology (BH) domains, which are characterized by both sequence and structural similarities, and are essential for their interactions and functions.

retrieved 19 October 2023 from https://phys.org/news/2023-10-structure-destabilizing-mutations-bcl-antiapoptotic-protein.html

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