Study findings could pave the way for development of new strategies to prevent and treat obesity UniofNottingham CellRepMed
, and a reduction in appetite—though the reasons for this are unknown. Bile acids are a marker of poor cardiometabolic health that can affect liver function and inflammation.by researchers from the University of Nottingham, King's College London and Amsterdam University Medical Center, has shed light on the molecules underlying the benefits of this kind of surgery on patient appetite and metabolism.
The study found that a specific bile acid called isoursodeoxycholate , which is associated with higher appetite and worse metabolic levels, decreased after bariatric surgery and after taking fiber supplements. Levels of isoUDCA did not decrease after consuming omega-3 supplements. "What our study shows is that specific microbial metabolite is involved in some of these benefits and that, although to a more modest extent,might mimic some of these effects," says Valdes."This could help design dietary supplementation studies aimed at increasing satiety and improving liver parameters."
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