Study finds no association between gout and neurodegenerative diseases in the general population EwhaWomansUniv Gout NeurodegenerativeDisease GeneralPopulation
Background Gout is a common and complex form of inflammatory arthritis characterized by severe joint pain. The condition is caused by impaired purine metabolism, leading to the accumulation of uric acid in the blood and the formation of monosodium urate crystals. These urate crystals are deposited in the joints, causing inflammation and severe pain.
Oxidative stress is a major hallmark of neurodegenerative diseases. With its potent antioxidant property, uric acid seems to have a positive impact on these conditions. Since gout is characterized by excess accumulation of uric acid in the blood, it is possible to have an association between the pathogenesis of gout, Alzheimer’s disease, and Parkinson’s disease.
The participants belonging to the gout group were matched with the comparison group participants at a ratio of 1:4 in terms of age, sex, monthly income, and residential area.
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