The recent BMJ Oncology study finds that using MRI screenings based on age can effectively identify prostate cancer risks independent of traditional PSA levels. The findings suggest that an MRI-based approach could be a more accurate alternative for prostate cancer screening, particularly for men with PSA levels lower than 3.0 ng/mL.
By Dr. Priyom Bose, Ph.D.Aug 27 2023Reviewed by Benedette Cuffari, M.Sc. A recent BMJ Oncology study screens the prevalence of prostate magnetic resonance imaging lesions in men based on age rather than prostate-specific antigen levels.
The European Randomized Screening study for Prostate Cancer proposed that systematic screening can significantly reduce the prevalence of prostate cancer mortality. However, the introduction of screening programs based on PSA and standard transrectal biopsy has been associated with overdiagnoses, which ultimately leads to unnecessary continued monitoring or overtreatment, both of which increase healthcare costs.
The PROMIS study revealed that individuals with MRI lesions scoring four out of five were at a 50% increased risk of prostate cancer, whereas those with five out of five scores were at a 70% increased risk of prostate cancer. These findings indicate a positive association between histological score and prostate cancer incidence.
Two radiologists independently scored the MRI findings as positive or negative. Men with a positive sMRI or PSA density of at least 0.12 ng/mL were considered screen-positive. Screen-negative participants were excluded from the study. Screen-positive individuals were referred to the National Health Service for further assessment for cancer.
Moreover, one in six men had a screen-positive MRI, whereas one in twenty men tested positive for PSA density alone. Most men with a screen-positive MRI had PSA levels less than 3.0 ng/mL. The current study began before the onset of the coronavirus disease 2019 pandemic, which subsequently paused participant recruitment between April 2020 and August 2020, after which the process restarted. However, many individuals avoided visiting healthcare facilities due to the pandemic.
Deutschland Neuesten Nachrichten, Deutschland Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Individuals feel sex-specific symptoms before impending cardiac arrest, study findsInvestigators from the Smidt Heart Institute at Cedars-Sinai are one step closer to helping individuals catch a sudden cardiac arrest before it happens, thanks to a study published today in The Lancet Digital Health journal.
Weiterlesen »
Study could explain why astronauts' T cells become less effective at fighting infectionA new study led by researchers at Karolinska Institutet in Sweden has examined how T cells of the immune system are affected by weightlessness.
Weiterlesen »
Cardiac arrest patients should be taken to nearest A&E over specialist centre, study suggestsResearch finds no difference in the survival between those taken by ambulance to the different hospitals.
Weiterlesen »
Adult interpersonal violence or childhood abuse, neglect increase later diabetes riskBoth adult interpersonal violence or abuse and childhood abuse or neglect increase the risk for adult-onset diabetes, according to a study recently published in the American Journal of Preventive Medicine.
Weiterlesen »
AI model can respond appropriately to ophthalmology questionsLarge language models (LLMs) like ChatGPT can respond to patient-written ophthalmology questions and usually generate appropriate responses, according to a study published online Aug. 22 in JAMA Network Open.
Weiterlesen »