The genetic overlap between Alzheimer's disease (AD) (a neurodegenerative disorder causing memory loss and cognitive decline), lipid profiles, and coronary artery disease (CAD).
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMAug 20 2024 In a recent study published in the International Journal of Molecular Sciences, a group of researchers systematically evaluated the genetic overlap between Alzheimer's disease , lipid profiles, and coronary artery disease traits using large-scale genetic data and robust analytical methods.
However, the precise relationships and underlying biology remain unclear, highlighting the need for further research to understand these complex connections better. The analysis also considered the relationship between AD and seven CAD traits, using data sourced from the Lee Lab for Statistical Genetics and the CARDIoGRAMplusC4D consortium.
However, Mendelian randomization analyses did not support a causal link, suggesting shared genetic susceptibility as a more plausible explanation. Local genetic correlation analyses pinpointed specific genomic loci contributing to these associations, offering further insight into the complex genetic landscape linking AD with cardiovascular health.
The study applied bi-directional two-sample Mendelian randomization analyses to test for potential causal associations between these traits. However, the 2SMR analyses did not provide evidence for a causal relationship between AD, lipids, and CAD traits, indicating that the observed correlations might be due to shared genetic susceptibility rather than direct causal links.
Coronary Artery Disease Genetic Metabolism Brain Cholesterol Gene Genes Genetics Genome Genomic Heart High-Density Lipoproteins Lipids Neurodegenerative Disorder Research
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