A woman's fertility normally decreases by her late 30s with reproductive function eventually ceasing at menopause.
Reviewed by Lily Ramsey, LLMOct 18 2023 It is known that a small molecule called nicotinamide adenine dinucleotide plays a critical role in this decline, and Buck scientists have revealed how this happens and have identified potential new approaches to enhance reproductive longevity.
"So we knew that NAD was really important in promoting ovarian function, but what we didn't know is why it declines in the first place, what is the driver of this decline?" she said. The team found that CD38 was primarily found in ovarian immune cells and located in specific structures outside the ovarian follicles.
Showing that CD38 regulates ovarian function and fertility through NAD+ metabolism means that targeting this molecule may offer new approaches to enhance reproductive longevity.
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