Researchers found that adherence and persistence in T2D patients using oral semaglutide is similar to DPP-4i, but semaglutide users required fewer concurrent medications, indicating higher long-term efficacy.
By Hugo Francisco de SouzaReviewed by Susha Cheriyedath, M.Sc.Jul 16 2024 In a recent large-scale retrospective cohort study published in the journal Primary Care Diabetes, researchers used a comprehensive database-derived dataset to evaluate the adherence and persistence of newly initiating oral semaglutide type 2 diabetes patients compared to dipeptidyl peptidase-4 inhibitor users.
Background Type 2 diabetes is a chronic condition characterized by abnormally high blood sugar levels as a result of the body's inability to produce or utilize insulin properly. The International Diabetes Federation estimates that 11.3% of all adults have diabetes , with more than 90% of these patients having T2D. In the United States alone, more than 95% of its 37 million diabetic patients report T2D, with projections expecting this prevalence to only increase in the coming decades.
About the study The present study evaluated US-based T2D patient adherence and persistence to semaglutide by comparing their patterns to those of DPP-4i. The study was a non-interventional, retrospective, cohort-based study using data from two administrative healthcare databases – the Merative MarketScan Commercial and the Medicare databases. These databases contain data across age groups and from all 50 US states.
Study findings After excluding participants with missing data, the final dataset comprised 5,485 and 4,980 T2D patients prescribed semaglutide and DPP-4i, respectively. Ps-IPW analyses revealed that demographic characteristics between both cohorts were statistically comparable, with 'out-of-pocket costs' and obesity being the only exception. Semaglutide costs amounted to an average of $103 compared to the DPP-4i average of $67 per 30 days.
Semaglutide Type 2 Diabetes Blood Blood Sugar Chronic Efficacy GLP-1 High Blood Sugar Insulin Primary Care
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