In a new study co-led by investigators at the United States Department of Veterans Affairs and Brigham and Women's Hospital, a founding member of the Mass General Brigham health care system, a global team of scientists conducted one of the largest genetic association studies on heart failure to date. Using genomic data from over 90,000 heart failure patients and more than a million controls, the team identified 39 genetic mutations associated with heart failure, 18 of which had not been reported previously.
The researchers also pinpointed seven druggable proteins that, when targeted with specially designed medications, may prevent heart failure's onset. They say their overall findings, published today in, could one day help physicians identify and treat at-risk patients before heart failure occurs.
Heart failure affects over 60 million people worldwide and 6 million people in the United States, costing the American health care system over 30 billion dollars every year.
The team built their large cohort by gathering genomes from two established genomic research programs. The Million Veteran Program , a national effort launched in 2011 to examine the long-term health outcomes of United States Veterans, provided 302,287 genomes for the study. Heart failure is a particular concern for veterans, with some studies showing that they may be at a higher risk of developing heart disease. To date, over 950,000 veterans have enrolled in MVP.
The remaining 977,323 genomes were pulled from the Heart Failure Molecular Epidemiology for Therapeutic Targets consortium, which includes data from patients across several European countries. In total, the team analyzed 1,279,610 genome samples, 90,653 of which belonged to patients with heart failure.
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