Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with chronic neurodegeneration and related impairments due to TBI.
University Hospital s Cleveland Medical CenterSep 11 2024 Violent blows or jolts to the head can cause traumatic brain injury , and there are currently about five million people in the U.S. living with chronic neurodegeneration and related impairments due to TBI. In addition to cognitive and mental health impairment, chronic neurodegeneration may also contribute to why TBI increases the risk of age-related neurodegenerative diseases , such as Alzheimer's or Parkinson's disease.
We started with the hypothesis that TBI might pathologically impair the balance of mitochondrial fission and fusion. The normal homeostatic balance of mitochondrial fission and fusion is how mitochondria consistently produce enough energy for the cell while also sequestering and disposing damaged parts. Given the very high energy demands of the brain, this is particularly important for brain health across our lifespan.
"Brief P110 treatment during the acute time period after TBI permanently normalized mitochondrial fission / fusion and prevented subsequent harm to the brain, including oxidative damage, blood-brain barrier deterioration, axonal degeneration, and cognitive impairment, 17 months later. This is equivalent to many decades in people," explained Andrew A.
The team hopes that P110 or a related compound will be tested clinically in acute TBI patients. "Next steps in the basic science research, on the other hand, involve further utilization of this model to yield additional new insights into understanding the pathophysiology and treatment opportunities for this important problem," explained Dr. Qi.
Chronic Neurodegeneration Traumatic Brain Injury Blood Cancer Cell Children Encephalopathy Hospital Medicine Mental Health Neurodegenerative Diseases Research
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