Substance use disorders, including alcohol, tobacco, cannabis, or opioids, appear to share a common genetic signature, suggest new findings that researchers say could eventually lead to universal therapies to treat multiple and comorbid addictions.
Substance use disorders , including alcohol, tobacco, cannabis, or opioids, appear to share a common genetic signature, suggest new findings that researchers say could eventually lead to universal therapies to treat multiple and comorbid addictions.
The risk of developing SUDs is influenced by a complex interplay between genetics and environmental factors. In a genome-wide association study , the investigators looked for variations in the genome that were closely associated with SUDs in more than 1 million people of European ancestry and 92,630 people of African ancestry.
The genomic pattern also predicted higher risk of mental and physical illness, including psychiatric disorders, suicidal behavior, respiratory disease, heart disease, and chronic pain conditions. In children aged 9 or 10 years, presumably without any SUD, these genes correlated with parental substance use and externalizing behavior.
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