A new study has shown that taking a single dose of a widely used, cheap antibiotic within 3 days after condomless sex can help prevent chlamydia, syphilis, and gonorrhea.
A new study has shown that taking a single dose of a widely used, cheap antibiotic within 3 days after condomless sex can help prevent chlamydia, syphilis, and gonorrhea, three sexually transmitted infections that have soared in the United States, Europe, and elsewhere over the past 2 decades.
Doxycycline, a relative of the antibiotic tetracycline, has been around for more than 45 years and is commonly used to treat and prevent acne and Lyme disease. It also acts on parasites and is widely prescribed to prevent malaria in travelers. The drug typically has few side effects beyond stomach upset and increased sensitivity to sunlight.
The new study enrolled 544 participants—mostly MSM, but also some transgender women and gender diverse people—deemed at high risk for STIs. Two-thirds of them were asked to follow a protocol similar to the one in the French study. The remaining participants received standard STI testing and treatment. Everyone knew what group they were in.
, unlike the bacteria that cause the other two STIs, readily develops resistance. DoxyPEP will make that worse, Molina predicts—“That’s a no-brainer.” What will happen with chlamydia and syphilis, which have not yet evolved to resist antibiotics, “we don’t know—we hope,” he says.
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