The ‘breakthrough’ obesity drugs that have stunned researchers

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The ‘breakthrough’ obesity drugs that have stunned researchers
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Semaglutide is one of a new generation of anti-obesity medications that have shown striking results in trials and in practice. But can these drugs help all people with obesity — and conquer weight stigma?

The presentation concluded like no other at the conference, says Yanovski, co-director of the Office of Obesity Research at the US National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Maryland. Sustained applause echoed through the room “like you were at a Broadway show”, she says.

However, some researchers worry that these drugs play into some societies’ obsession with being thin. Body size isn’t always a good predictor of health. “I’m really hesitant to be excited about something that I think is potentially harmful from a weight stigma perspective,” says Sarah Nutter, a psychologist at the University of Victoria in Canada, who specializes in weight stigma and body image.

An explosion of research into obesity’s underpinnings followed, alongside research into pharmacological treatments. But these early drugs led to only modest weight loss and serious side effects, especially on the heart.

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