The development of the pediatric oral resistome and its role in dental caries NatureComms Sydney_Uni UCLA UniofAdelaide oral dental oralhealth pediatrics resistome AMR caries
By Neha MathurMar 14 2023Reviewed by Danielle Ellis, B.Sc. In a recent article published in Nature Communications, researchers performed a genomic investigation of oral resistome development, i.e., of genes that confer antimicrobial resistance .
In childhood, diet, the introduction of solid foods, and the emergence of teeth change the composition of the oral microbiome. Host genetics also comes into play and influences ARG-carrying oral bacteria during childhood. However, it has remained unexplored how commensal and pathogenic bacteria in the oral microbiome acquire and develop AMR during childhood.
In addition, they showed how it significantly changed in composition with other microbiome constituents over the first decade of life and in response to changes in oral health, e.g., dental caries and placement of restorations. Omics eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Although scientists have observed that oral resistome accounts for less than 1% of the known microbiome, in this study, they observed that AMR-related mobile genetic elements were extensively prevalent, for instance, the Tn916 transposase family. Another remarkable finding was that the mobilization potential of ARGs increased with the age of children. Moreover, genetics and environment, e.g.
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