Gut dysbiosis among critically ill individuals
By Pooja Toshniwal PahariaAug 16 2023Reviewed by Lily Ramsey, LLM In a recent review published in the Nutrients Journal, researchers reviewed existing evidence on gut dysbiosis among critically ill individuals and the re-establishment of microbial diversity in the gut by probiotics and immunonutrition in the severely diseased population.
About the review In the present review, researchers described the gut microbiome of critically ill individuals and its modulation by probiotics and immunonutrition. Anti-inflammatory medications such as immunosuppressants, non-steroidal anti-inflammatory drugs, and steroids can lower the cytokine-induced hyperinflammation in coronavirus disease 2019 patients; however, they may be insufficient to prevent tissue injury.
ICU patients have demonstrated an increased abundance of microbes such as Clostridium, Lactobacillus, Enterococcus, Bacteroides, Streptococcus, Pseudomonas, Prevotella, Corynebacterium, Acinetobacter, Bifidobacterium, and Actinomyces. In contrast, microbes such as Fusobacterium, Akkermansia, and Faecalibacterium have lowered abundance among critically ill patients.
Probiotic use has also significantly reduced the incidence rates of ventilator-associated pneumonia , infectious complications, and deaths.
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