The identification of vaccinee-derived antibodies with broad-spectrum Omicron neutralization activity CellReports antibodies monoclonal mAbs covid COVID COVID19 SARSCoV2 omicron research vaccines
By Dr. Liji Thomas, MDApr 12 2023Reviewed by Lily Ramsey, LLM A recent study posted in the Cell Reports Journal reported the identification of a panel of vaccinee-derived antibodies with broad-spectrum neutralization activity.
These could shed light on the road ahead for developing such broad-spectrum agents for treating coronavirus-induced disease outbreaks. The Omicron VOC was first identified in South Africa in the latter part of 2021 and has comprised over 98% of all publicly available genomic sequences since February 2022.
What did the study show? The current study isolated several such antibodies from a Californian individual who had taken two doses of the Moderna mRNA-1273 COVID-19 vaccine. With three of them, which bind to the receptor binding domain, RBD-2, each fragment antigen-binding from one antibody interacts with one spike monomer from the top of the receptor binding motif . This causes the RBDs to become upright.
The scientists also found that with some of these mAbs, the high avidity for the spike variant overcame the relatively lower affinity.
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