The interaction between white adipose tissue mitochondria and gut microbiota in obesity Adipose Microbiome Mitochondria Obesity gut microbiota crosstalk unitorvergat Nutrients_MDPI istsupsan
By Bhavana KunkalikarApr 4 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Nutrients journal, researchers explored the interaction of white adipose tissue mitochondria with gut microbiota in obesity.
Mitochondria are intracellular organelles that coordinate energy production and experience highly dynamic adaptive changes in reaction to changing environments. BAT represents a minimal proportion of body weight. The quantity is greater in newborns, tends to decline in adults, and is still present in the supraclavicular region, and in trace amounts around the great vessels in the paravertebral and mediastinal regions.
In addition, a recent review noted that some taxa, like Christensenellaceae and Akkermansia, may promote gut homeostasis and healthy aging by lowering adiposity, inflammation, and the ensuing risk of developing metabolic and cognitive dysfunction in addition to the higher bacterial diversity. The gut microbiome of obese people with healthy and unhealthy metabolisms was compared. Compared to their metabolically healthy obese equivalent, obese individuals with multiple comorbidities showed a substantial decrease in the variety of their gut microbiota.
Furthermore, it was discovered that microbiota-depleted rodents displayed improved insulin sensitivity and glucose tolerance in addition to a rise in the expression of fat browning markers.
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