The race to develop a COVID-19 vaccine explained
“is going to be, at the earliest, a year to a year and a half” before a vaccine is deployable, “no matter how fast you go.”
Hotez and his longtime collaborator Dr. Maria Elena Bottazzi spent nearly 20 years developing a vaccine for SARS-1, which infected hundreds in Asia and Canada in the early 2000s, but ultimatelybefore entering clinical trials because they ran out of funding.
There are other risks to accelerating the testing process. Experts have cautioned about the potential for a vaccine to make the disease worse, an issue that emerged in animal testing for SARS-1. COVID-19 also has a relatively high asymptomatic infection rate , which means a larger testing pool is ideal, and the likelihood of re-exposure, which is far greater than that of SARS-1, means a longer-term evaluation period is preferable. Unfortunately, it’s not an option.
Also of concern to Offit is the prospect of the FDA forgoing the approval process entirely. “I worry they’re going to use Emergency Use Authorization to get around the FDA,” he says. “I think that would be a mistake. I really do. Although we see regulation as burdensome, you want the FDA to regulate these products. You want someone to take a long hard look at what the data are before they license it for use in this country.
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