“If we could control this hangry feeling, we might be better able to control our diets.” (via KnowableMag)
also play important roles, he says. That’s why, for example, you eat that slice of pumpkin pie at the end of the Thanksgiving meal, even though you’re already full of turkey and mashed potatoes.
Researchers can study the condition using a mouse model of the disease known as activity-based anorexia, or ABA. When scientists limit the food available to the mice and provide them with a wheel to run on, some mice enter an anorexia-like state, eating less than they’re offered, and running on the wheel even during daylight, when mice are normally inactive. “It’s a remarkable addictive thing that happens to these animals,” says Tamas Horvath, a neuroscientist at the Yale School of Medicine.
To find out how AgRP neurons might be involved in anorexia, Sutton Hickey carefully monitored the food intake of ABA mice. She compared them to mice that were given a restricted diet, but had a locked exercise wheel and didn’t develop ABA. The ABA mice, she found, ate fewer meals than the other mice. And when they did eat, their AgRP activity didn’t decrease like it should have after they filled their tummies.
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