Gut health supplements can be a helpful way to manage the good bacteria in your microbiome. But make sure you choose your probiotics wisely, says Dr Megan Rossi.
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Irinotecan-gut microbiota interactions and the capability of probiotics to mitigate Irinotecan-associated toxicity - BMC MicrobiologyBackground Irinotecan is a chemotherapeutic agent used to treat a variety of tumors, including colorectal cancer (CRC). In the intestine, it is transformed into SN-38 by gut microbial enzymes, which is responsible for its toxicity during excretion. Objective Our study highlights the impact of Irinotecan on gut microbiota composition and the role of probiotics in limiting Irinotecan-associated diarrhea and suppressing gut bacterial β-glucuronidase enzymes. Material and methods To investigate the effect of Irinotecan on the gut microbiota composition, we applied 16S rRNA gene sequencing in three groups of stool samples from healthy individuals, colon cancer, and Irinotecan treated patients (n = 5/group). Furthermore, three Lactobacillus spp.; Lactiplantibacillus plantarum (L. plantarum), Lactobacillus acidophilus (L. acidophilus), Lacticaseibacillus rhamnosus (L. rhamnosus) were used in a single and mixed form to in-vitro explore the effect of probiotics on the expression of β-glucuronidase gene from E. coli. Also, probiotics were introduced in single and mixed forms in groups of mice before the administration of Irinotecan, and their protective effects were explored by assessing the level of reactive oxidative species (ROS) as well as studying the concomitant intestinal inflammation and apoptosis. Results The gut microbiota was disturbed in individuals with colon cancer and after Irinotecan treatment. In the healthy group, Firmicutes were more abundant than Bacteriodetes, which was the opposite in the case of colon-cancer or Irinotecan treated groups. Actinobacteria and Verrucomicrobia were markedly present within the healthy group, while Cyanobacteria were noted in colon-cancer and the Irinotecan-treated groups. Enterobacteriaceae and genus Dialister were more abundant in the colon-cancer group than in other groups. The abundance of Veillonella, Clostridium, Butryicicoccus, and Prevotella were increased in Irinotecan-treated groups compared to other groups. Using La
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The Gut Life Weekend with Stylist x YakultDelve into everything gut health this 24–25 June with eight expert-led sessions at Stylist x Yakult's The Gut Life Weekend. Tickets are £10 per session, so you don't need to be available all weekend to join in. See you there! TheGutLifeWeekend Yakult
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Gut health boost: Functional foods and herbs show promise in tackling SARS-CoV-2 variantsFunctional foods and natural herbs have the potential to enhance immune function and maintain gut microbiota diversity. This review explores their role in mitigating the impact of SARS-CoV-2 variants on gut health and overall well-being.
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17 subtle signs of cheating to watch out forIf your gut is really trying to tell you something, these tips could prove useful.
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Enter, the very best sunscreens and face SPFs to have on your radar – just in time for the heatwave!Face SPF should be your skin's best friend.
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Gut health boost: Functional foods and herbs show promise in tackling SARS-CoV-2 variantsFunctional foods and natural herbs have the potential to enhance immune function and maintain gut microbiota diversity. This review explores their role in mitigating the impact of SARS-CoV-2 variants on gut health and overall well-being.
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