Thousands of genetic variants may influence how many alcoholic drinks we have a week, the age some start smoking and whether they quit the habit
, which influences the survival of neurons that secrete dopamine.
In another part of the study, the team used this genetic variant information to predict smoking habits and alcohol consumption in a separate group of 6092 people of European descent living in the US.When these European-based risk scores were applied to almost 4000 people of African, East Asian or North or South American descent, however, the results were less accurate.
The team didn’t assess genetic variants that are known to occur in fewer than 1 in 1000 people, which could be done in the future using larger sample sizes, says Liu. “This is a great study. It demonstrates the power of using large samples from multiple ancestry groups in well-designed analyses,” says“It’s overall a substantial advance in our understanding of the genetics, and therefore the biology, of smoking traits and alcohol drinks per week,” he says.
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