Researchers explore the therapeutic potential of circadian-modulating interventions to treat Alzheimer’s disease.
By Dr. Priyom Bose, Ph.D.Aug 27 2023Reviewed by Benedette Cuffari, M.Sc. A recent Cell Metabolism study explores the therapeutic potential of circadian-modulating interventions to treat Alzheimer's disease .
Many AD patients also exhibit behavioral changes, such as confusion in the evening, which is referred to as sundowning. These symptoms are associated with decreased survival or nursing home placement. Deletion of the core circadian clock genes Bmal1 and Per1 in mice triggers oxidative damage and synaptic degeneration. Furthermore, this condition manifests as impaired cortical connectivity, behavioral abnormalities, and weakened memory. These observations strongly indicate how alterations in the circadian clock impact neuronal viability and cognitive function.
Related StoriesThe current study used two mouse models of AD to assess whether circadian intervention based on TRF at the early disease stage can alleviate transcriptional alterations, improve behavior, and ameliorate pathology. APP23 TG mice without diurnal oscillation in genes exhibited hyperexcitability and reduced sleep. Orexin is a neurotransmitter expressed in the hippocampus that controls sleep, motivated behavior, and excitability. Several AD mouse models revealed reduced orexin and its receptors, which leads to sleep disturbances and behavioral issues.
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