Tissues, not blood, are where immune cells function

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Tissues, not blood, are where immune cells function
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Comment: COVID has shown we must study immunity in the whole body — let’s sort the logistics to acquire the right samples

Many and variable: brain, liver, lungs, intestines, kidney, pancreasLungs, intestines, spleen, lymph nodes, bone marrow, pancreas, salivary glands, skin, thymusBlood vessels, tumours, lungs, intestines, tonsils, skin, reproductive organsIntestines, lungs, lymph nodes, pancreas, skin, breast, kidneyPeople treated for infections or respiratory distress; recipients of organ transplantsHealthy people, and people with infections, asthma, chronic lung diseasesTen years ago, my team set up a new type...

Technological advances mean that RNA transcripts, protein content and gene modifications can be pinpointed even for single cells. Combined with computational analyses, these measurements allow the simultaneous identification of immune-cell composition, lineage and functional states.

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