Tracking malaria parasites in space and time nature
. This atlas of the liver stage of the malaria infection is crucial because solving the infection at this stage would prevent the development of the disease.in the liver by looking at the localization of the parasites over time and were able to create an atlas of the liver infection by applying an innovative approach.that are organized in the shape of hexagons. We found that the outcome of the infection is different depending on the zone of the lobules infected by the malaria parasites.
The research team analyzed the active genes of the liver cells and the parasites at different times after infection, using mice as a model. Since the genes that are active in the liver cells depend on their localization, the researchers were able to pair each parasite to its localization in the liver and reconstruct their paths by checking over the time of the infection.
"We called these cells in the liver where the parasites are not able to develop an infection 'abortive liver cells'," says Maria Manuel Mota, group leader at the iMM and co-leader of the study."It's almost as if these cells are hostile to the parasites and the parasites have to 'abort the mission'. We found that thethat these cells are able to promote in response to the parasites is different," explains Maria Manuel Mota.
The researchers created a detailed atlas of the infection by the parasites that cause malaria in the liver. Deciphering the dynamics of the infection at this asymptomatic stage is important because it will feed the research on how to stop the infection in the liver and eliminate the disease before the symptoms.
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