A study published in Molecular Medicine finds that the Transient Receptor Potential Ankyrin-1 channel, a pro-inflammatory detector, also plays a specific anti-inflammatory role via nervous system regulation of anti-inflammatory responses.
). Briefly, mice were anesthetized using isoflurane at 2.5% in 100% oxygen at a flow rate of 1 L/min, and maintained in supine position at 1.5% isoflurane on a heating pad to maintain core body temperature around 37 °C. The cervical vagus nerve was then exposed and placed on the recording electrode. Recordings were sampled at 40 kHz with a 120 Hz filter and 1:50 gain at 1.25% isoflurane.
Cre/Gq-DREADD mice were subjected to either chemogenetic stimulation receiving either clozapine N-oxide at 5 mg/kg or vehicle 1 h prior to LPS administration ; or direct application of clozapine N-oxide or vehicle to the vagus nerve for 5 min. Following direct application of clozapine N-oxide to the vagus nerve, mice were recovered for 2 h prior to LPS . Animals were euthanized by COasphyxiation 90 min post-LPS administration and blood was collected by cardiac puncture.
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