Brain-specific inhibition of the TORC1 protein complex.
Medicinal chemists and pharmacologists dream about how drugs might be directed specifically to selected organs.
A particularly challenging target is the brain: many drugs do not pass easily through the blood–brain barrier , or are actively pumped out of the brain. The situation is complicated further when a drug to be delivered also shows body-wide adverse effects. One such drug is rapamycin, which blocks tumour growth, but is also used as an immunosuppressant during organ transplantation
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