But many scientists consider human challenge trials with the coronavirus unethical because there are no 'rescue therapies' for those who fall ill.
That includes efforts to manufacture a suitable SARS-CoV-2 strain, draft a clinical protocol and identify resources that would be required to conduct such studies.
Such trials are typically done when a virus is not widely circulating, which is not the case with COVID-19. Many scientists consider human challenge trials of the novel coronavirus unethical because there are no"rescue therapies" for those who fall ill. Van Hoof said such trials would offer a testing option in case the virus stops circulating widely, but the company would only move forward with such trials if the ethical issues are resolved and an effective treatment is available.Dr.
Dr. Dan Barouch, a vaccine researcher at Harvard's Beth Israel Deaconess Medical Center in Boston, who helped design and conduct animal studies on J&J's COVID-19 vaccine, said he is not aware of any manufacturers planning human challenge studies.
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