A College of Medicine researcher is developing a new antibiotic related to penicillin to treat tuberculosis (TB) and related lung infections.
Dr. Kyle Rohde, an infectious disease expert, recently received a $3.4 million, five-year grant from the National Institutes of Health to create new antibiotics that target mycobacterial infections caused by pathogens such as Mycobacterium tuberculosis and Mycobacterium abscessus.
Thankfully, only 1 in 10 people who get infected develop symptoms in the short term. But infected people who don't get sick right away can still develop so-called latent infections and can be carriers for years. If the infection is not detected and treated early on, the bacteria can enter the patient's bloodstream and spread to various parts of the body such as bones, brain and liver." Although rare in the U.S.
Dr. Rohde's research aims to develop new treatments that shorten treatment times, eradicate drug-resistant strains and minimize side effects. In collaboration with chemist Dr. John Buynak of South Methodist University in Texas, Dr. Rohde's team will synthesize and test "next-gen" carbapenem drugs that they can optimize to target TB. The optimized antibiotics will be designed to resist enzymes the bacteria use to inactivate the drug while also destroying the bacteria's cell wall.
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