In a mouse study, UCLA researchers tested a vaccine against the bacterium that causes melioidosis and found it was highly protective against the disease, which is endemic in many tropical areas, causing approximately 165,000 cases with 89,000 fatalities around the world each year.
Mar 22 2024University of California - Los Angeles Health Sciences
To date there are no licensed vaccines against the bacterium, said senior author Dr. Marcus Horwitz, Distinguished Professor of Medicine, in the division of infectious diseases, and of Microbiology, Immunology and Molecular Genetics at the David Geffen School of Medicine at UCLA. They administered the new vaccine through both skin injection and intranasal delivery in a strain of mice that is particularly sensitive to B. pseudomallei lung infection. The researchers found that the vaccine was not only safe and non-toxic, but effective even against a highly lethal strain of the melioidosis bacteria. Intranasal administration provided better protection than skin injection, with just a single dose proving effective with long-lasting protection.