Understanding the mysterious cells in the brain's visual cortex

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Understanding the mysterious cells in the brain's visual cortex
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Imagine yourself sometime in the far future aboard a routine rocket to Mars. Someone just spilled their drink. Without gravity, it collects in floating blobs that ripple right before your eyes. Now freeze.

Cold Spring Harbor Laboratory Oct 10 2024

The visual cortex processes everything we see. Incoming visual information is relayed to this outer layer of the brain via synapses-;the silver streaks above. When the brain's neural circuits are first wired up, more connections, or synapses, are created than needed. As the brain accumulates new experiences and information, OPCs shape neural circuitry by pruning unnecessary synapses.

"We're able to see what thousands of OPCs, and even smaller groups of 30-50, are doing," he explains. "From there, we can figure out which synapses are fully engulfed by an OPC, which are in the process of being pruned, and which have maybe just been checked on by an OPC but not processed." It'll take more research to illustrate these connections in detail. In the meantime, Cheadle is eager to share his lab's new tools with researchers around the world. "The brain is constantly changing, and the same approaches you'd use to look at one type of cell can't just be applied across the board," he says. "We're adapting and innovating to keep up with it-;to better understand how the brain works.

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