The study used a genome-wide association study (GWAS) to analyze random glucose levels in nearly half a million non-diabetic subjects, uncovering 150 distinct genetic signals, including 53 new ones, linked to glycemic traits and type 2 diabetes. The research also discovered a causal effect of random glucose and type 2 diabetes on lung function, identifying lung dysfunction as a new diabetes complication.
By Neha MathurSep 10 2023 A recent study published in the journal Nature Genetics performed a genome-wide association study meta-analysis of random glucose .
Study: GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification. Tatiana Shepeleva / Shutterstock Notably, sex dimorphism was discovered at 13 RG loci. The lead variants at three previously reported FG loci and two new RG loci were common coding variants .
Related StoriesThe researchers noted that mini-Gs coupling efficiency was predictive of the RG effect of the variants, linking experimentally determined function of GLP-1R to blood glucose homeostasis. In addition, complementary functional annotation analyses were undertaken to identify other tissue and cell types with etiological roles in glucose metabolism.
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