Many life-saving medications interact directly with DNA to treat illnesses like cancer, but scientists have faced difficulties in understanding how and why they work - until now. Researchers from the University of Cambridge have presented a new DNA sequencing method in a paper published in the jo
Researchers have created a new DNA sequencing technique called Chem-map, which enables researchers to perform in situ mapping of small molecule-genome interactions with unparalleled precision.to treat illnesses like cancer, but scientists have faced difficulties in understanding how and why they work – until now.Nature Biotechnology
The powerful method, called Chem-map, lifts the veil of this genomic black box by enabling researchers to detect where small molecule drugs interact with their targets on the DNA genome. “Lots of life-saving drugs directly interact with DNA to treat diseases such as cancer,” said co-first author Dr. Jochen Spiegel. “Our new method can precisely map where drugs bind to the genome, which will help us to develop better drugs in the future.”
The technique was also used to map the binding sites of certain molecules on DNA G-quadruplexes, known as G4s. G4s are four-stranded secondary structures that have been implicated in gene regulation and could be possible targets for future anti-cancer treatments.
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