The findings pave the way for further exploration of RNA in cancer and the development of innovative cancer treatments.
Melanoma is a type of skin cancer that develops from melanocytes, the pigment-producing cells in the skin. It is considered the most dangerous form of skin cancer due to its tendency to spread to other parts of the body.have undoubtedly improved treatment options for melanoma patients. However, scientists continuously seek new approaches to tackle difficult-to-treat subsets of melanoma that rely on oncogenic gene expression for growth and resistance to therapy.
through an unusual mechanism: the impairment of a cell's ability to eliminate defective RNA strands, often referred to as the cell's "trash."on April 21. It has broad implications because this mechanism seems to be present across various malignancies. The findings could potentially unlock a new range of molecules that cancer drugs can target.
Insco's investigations involving zebrafish revealed that mutations in CDK13 accelerated melanoma development. Astonishingly, similar mutations were also found in numerous human melanomas.However, the true surprise is in understanding how the CDK13 mutation causes cancer. Insco observed multiple short, defective RNA molecules produced by melanoma cells. It was an abnormality, and she promptly shared it with Zon.
The team of researchers also discovered mutations in CDK13, ZC3H14, or related proteins in other types of human tumors, including non-melanoma skin cancer, endometrial cancer, colon adenocarcinoma, and small-cell lung cancer.
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