Using genetic risk scores for predicting venous thromboembolism Genetic Thromboembolism VenousThromboembolism Genetics Cardiovascular SportsMedicine PLOSONE UMNews UNC uvmvermont
By Bhavana KunkalikarFeb 5 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in PLoS One, researchers assess the predictability of venous thromboembolism among adults using genetic risk scores .
Currently, available VTE prevention techniques do not target the prevention of VTE within the general population. Furthermore, identifying individuals who are at a greater risk for experiencing VTE is difficult, as only a few practical risk scores that can facilitate the diagnosis of high-risk individuals have been published.
Between 1990 and 2019, ARIC maintained longitudinal contact with participants through either semi-annual or annual phone calls and six reexamination visits. GRS incorporated signals from several loci by adding the product of the effect sizes and the proportion of effect alleles present at each locus for all participants.
Study findings Between 1987 and 1989, 11,292 ARIC participants were included in the study, 54% of whom were female, 78% White, and 22% Black. The individuals reported a median score of 21.4 on the 273-variant GRS and 1.0 on the weighted, imputed five-variant GRS. Furthermore, ARIC identified 788 participants with VTE across an average of 28 years of follow-up. This included 467 provoked and 321 unprovoked cases.
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