Catharine E. Krebs: “Success will come from recognizing the need to reduce wasteful and poorly predictive animal experiments.'
. But there is opportunity to expand upon these programs and create new ones to ensure further progress in human-specific, nonanimal models.
Prioritizing human-specific approaches also allows researchers to recenter patients and communities. Animals are incapable of modelling social determinants of health or community interventions. The NIHaimed at pharmaceutical interventions diverts resources away from the kind of research that can address health disparities or that can prevent disease by addressing modifiable risk factors, such as environmental exposures.
Time will tell if Dr. Bertagnolli’s leadership will steer the agency away from the methodological inertia still slowing down progress and toward a human-focused research direction. What is indisputable is that vision and action are needed to renew the public’s confidence in the NIH to uphold its scientific charge. If Dr. Bertagnolli can pull off this difficult task, celebrations will be in order for both patients and animals alike.
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