Researchers found that valproic acid (VPA), especially when combined with DHA, significantly reduces SARS-CoV-2 infection rates and severity, potentially activating antiviral mechanisms. Epidemiologic data support VPA's role in reducing COVID-19 severity and hospitalization rates.
By Dr. Sushama R. Chaphalkar, PhD.Reviewed by Susha Cheriyedath, M.Sc.Aug 6 2024 In a recent study published in the journal PLOS ONE, researchers from the United States of America investigated the antiviral effects of valproic acid , alone and in combination with docosahexaenoic acid , against infection with severe acute respiratory syndrome coronavirus 2 .
In the present study, researchers conducted in vitro testing and epidemiologic analysis to investigate VPA's antiviral activity alone and in combination with DHA. They identified pitfalls in screening methods and proposed a potentially cost-effective strategy against certain coronaviruses. Further, epidemiologic data from the Optum dataset were analyzed to study COVID-19 outcomes associated with VPA use, and serum VPA levels were obtained from LabCorp for analysis.
Related StoriesAdditionally, LA and DHA were found to significantly inhibit viral replication when tested on HCoV-229E. DHA was found to enhance the antiviral effect of VPA, reducing the IC50 for viral replication inhibition. Combinations of VPA and DHA showed substantial antiviral synergy. Testing on SARS-CoV-2 revealed that VPA, DHA, and their combination inhibited viral replication, though preincubation did not improve effectiveness.
Valproic Acid Assay Bipolar Disorder Cancer Cancer Therapy Coronavirus Docosahexaenoic Acid Gene Gene Expression HIV Immunodeficiency In Vitro Intracellular Respiratory RNA SARS SARS-Cov-2 Seizure Severe Acute Respiratory Severe Acute Respiratory Syndrome Syndrome Virus
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